Methods:
Integrative set-up atomic force microscopy (AFM) with fluorescence microscopy
Combined fluorescence optical tweezers CTrap© system
Chromatography purification of recombinant proteins
Analytical ultracentrifugation
Agarose and polyacrylamide gel electrophoresis for DNA substrate and protein preparation and the study of protein-DNA interactions
Isothermal calorimetry (ITC)
Spectroscopic assays